Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

Specific inhibitors of mitogen-activated protein kinase/extra-cellular signal-regulated kinase (ERK) kinase (MEK) have been developed that efficiently inhibit the oncogenic RAF-MEK-ERK pathway. We used a systems-based approach to identify breast cancer subtypes particularly susceptible to MEK inhibi...

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Auteurs principaux: Mirzoeva, Olga K., Das, Debopriya, Heiser, Laura M., Bhattacharya, Sanchita, Siwak, Doris, Gendelman, Rina, Bayani, Nora, Wang, Nicholas J., Neve, Richard M., Guan, Yinghui, Hu, Zhi, Knight, Zachary, Feiler, Heidi S., Gascard, Philippe, Parvin, Bahram, Spellman, Paul T., Shokat, Kevan M., Wyrobek, Andrew J., Bissell, Mina J., McCormick, Frank, Kuo, Wen-Lin, Mills, Gordon B., Gray, Joe W., Korn, W. Michael
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737189/
https://ncbi.nlm.nih.gov/pubmed/19147570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3389
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