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No Sib Pair Concordance for Breast or Ovarian Cancer in BRCA1 Mutation Carriers

Modifying factors might theoretically determine whether a BRCA1 mutation carrier contracts breast or ovarian cancer. If so, one would expect concordance for breast or ovarian cancer in affected sibships. We identified 64 pairs with cancers where one or both sisters were demonstrated to carry a BRCA1...

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Bibliographic Details
Main Authors: Møller, Pål, Mæhle, Lovise, Clark, Neal, Apold, Jaran
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736994/
https://ncbi.nlm.nih.gov/pubmed/19725986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-5-2-67
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