High penetrances of BRCA1 and BRCA2 mutations confirmed in a prospective series

Penetrances of BRCA1 and BRCA2 mutations have been derived from retrospective studies, implying the possibility of ascertainment biases to influence the results. We have followed women at risk for breast and/or ovarian cancer for two decades, and report the prospectively observed age-related annual...

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Bibliografski detalji
Glavni autori: Møller, Pål, Mæhle, Lovise, Engebretsen, Lars F, Ludvigsen, Trond, Jonsrud, Christoffer, Apold, Jaran, Vabø, Anita, Clark, Neal
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828412/
https://ncbi.nlm.nih.gov/pubmed/20180971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-8-2
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