Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB

We describe a highly efficient use of lentiviral validation-based insertional mutagenesis (VBIM) to generate large populations of mammalian cells in which a strong promoter is inserted into many different genomic loci, causing greatly increased expression of downstream sequences. Many different sele...

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Hauptverfasser: Lu, Tao, Jackson, Mark W., Singhi, Aatur D., Kandel, Eugene S., Yang, Maojing, Zhang, Yi, Gudkov, Andrei V., Stark, George R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736141/
https://ncbi.nlm.nih.gov/pubmed/19805303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908560106
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