CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans

CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are being developed as a therapy for allergic indications and have proven to be safe and well tolerated in humans when administrated via the pulmonary route. In contrast, ISS inhalation has unexplained toxicity in roden...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Campbell, John D., Cho, Yan, Foster, Martyn L., Kanzler, Holger, Kachura, Melissa A., Lum, Jeremy A., Ratcliffe, Marianne J., Sathe, Atul, Leishman, Andrew J., Bahl, Ash, McHale, Mark, Coffman, Robert L., Hessel, Edith M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2009
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735936/
https://ncbi.nlm.nih.gov/pubmed/19726873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38294
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak