Immunostimulatory CpG Oligonucleotides: Effect on gene expression and utility as vaccine adjuvants

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate B cells and plasmacytoid dendritic cells (pDC), promote the production of Th1 and pro-inflammatory cytokines, and trigger the maturation/activati...

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Bibliografiske detaljer
Main Authors: Klinman, Dennis M., Klaschik, Sven, Tomaru, Koji, Shirota, Hidekazu, Tross, Debra, Ikeuchi, Hidekazu
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830905/
https://ncbi.nlm.nih.gov/pubmed/20188247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.10.094
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