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Immunostimulatory CpG Oligonucleotides: Effect on gene expression and utility as vaccine adjuvants
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate B cells and plasmacytoid dendritic cells (pDC), promote the production of Th1 and pro-inflammatory cytokines, and trigger the maturation/activati...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830905/ https://ncbi.nlm.nih.gov/pubmed/20188247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.10.094 |
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