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Synthetic oligonucleotides as modulators of inflammation

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate human B cells and plasmacytoid dendritic cells, promote the production of Th1 and proinflammatory cytokines, and trigger the maturation/activatio...

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Detalles Bibliográficos
Main Authors: Klinman, Dennis, Shirota, Hidekazu, Tross, Debra, Sato, Takashi, Klaschik, Sven
Formato: Artigo
Idioma:Inglês
Publicado: The Society for Leukocyte Biology 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538593/
https://ncbi.nlm.nih.gov/pubmed/18430787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1107775
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