CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans

CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are being developed as a therapy for allergic indications and have proven to be safe and well tolerated in humans when administrated via the pulmonary route. In contrast, ISS inhalation has unexplained toxicity in roden...

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Detalhes bibliográficos
Main Authors: Campbell, John D., Cho, Yan, Foster, Martyn L., Kanzler, Holger, Kachura, Melissa A., Lum, Jeremy A., Ratcliffe, Marianne J., Sathe, Atul, Leishman, Andrew J., Bahl, Ash, McHale, Mark, Coffman, Robert L., Hessel, Edith M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735936/
https://ncbi.nlm.nih.gov/pubmed/19726873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38294
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