CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans

CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are being developed as a therapy for allergic indications and have proven to be safe and well tolerated in humans when administrated via the pulmonary route. In contrast, ISS inhalation has unexplained toxicity in roden...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Campbell, John D., Cho, Yan, Foster, Martyn L., Kanzler, Holger, Kachura, Melissa A., Lum, Jeremy A., Ratcliffe, Marianne J., Sathe, Atul, Leishman, Andrew J., Bahl, Ash, McHale, Mark, Coffman, Robert L., Hessel, Edith M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2009
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735936/
https://ncbi.nlm.nih.gov/pubmed/19726873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38294
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια