Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

Aldosterone regulates volume homeostasis and blood pressure by enhancing sodium reabsorption in the kidney’s distal nephron (DN). On the apical surface of these renal epithelia, aldosterone increases expression and activity of the thiazide-sensitive Na-Cl cotransporter (NCC) and the epithelial sodiu...

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Hauptverfasser: Rozansky, David J., Cornwall, Tonya, Subramanya, Arohan R., Rogers, Shaunessy, Yang, Yong-Feng, David, Larry L., Zhu, Xiaoman, Yang, Chao-Ling, Ellison, David H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735908/
https://ncbi.nlm.nih.gov/pubmed/19690383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38323
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