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Leishmania major lacking arginase are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice

Polyamines are essential metabolites in eukaryotes participating in a variety of proliferative processes, and in trypanosomatid protozoa play an additional role in the synthesis of the critical thiol trypanothione. Whereas the polyamine biosynthesis arising from L-ornithine has been well studied in...

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Detalhes bibliográficos
Main Authors: Reguera, Rosa M., Balaña-Fouce, Rafael, Showalter, Melissa, Hickerson, Suzanne, Beverley, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735255/
https://ncbi.nlm.nih.gov/pubmed/19393161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2009.01.001
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