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Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts

Surface phosophoglycans such as lipophosphoglycan (LPG) or proteophosphoglycan (PPG) and glycosylinositol phospholipids (GIPLs) modulate essential interactions between Leishmania and mammalian macrophages. Phosphoglycan synthesis depends on the Golgi GDP-mannose transporter encoded by LPG2. LPG2-nul...

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Main Authors: Gaur, Upasna, Showalter, Melissa, Hickerson, Suzanne, Dalvi, Rahul, Turco, Salvatore J., Wilson, Mary E., Beverley, Stephen M.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720449/
https://ncbi.nlm.nih.gov/pubmed/19328787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exppara.2009.03.014
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