Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts

Surface phosophoglycans such as lipophosphoglycan (LPG) or proteophosphoglycan (PPG) and glycosylinositol phospholipids (GIPLs) modulate essential interactions between Leishmania and mammalian macrophages. Phosphoglycan synthesis depends on the Golgi GDP-mannose transporter encoded by LPG2. LPG2-nul...

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Hlavní autoři: Gaur, Upasna, Showalter, Melissa, Hickerson, Suzanne, Dalvi, Rahul, Turco, Salvatore J., Wilson, Mary E., Beverley, Stephen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720449/
https://ncbi.nlm.nih.gov/pubmed/19328787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exppara.2009.03.014
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