Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts

Surface phosophoglycans such as lipophosphoglycan (LPG) or proteophosphoglycan (PPG) and glycosylinositol phospholipids (GIPLs) modulate essential interactions between Leishmania and mammalian macrophages. Phosphoglycan synthesis depends on the Golgi GDP-mannose transporter encoded by LPG2. LPG2-nul...

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Bibliographic Details
Main Authors: Gaur, Upasna, Showalter, Melissa, Hickerson, Suzanne, Dalvi, Rahul, Turco, Salvatore J., Wilson, Mary E., Beverley, Stephen M.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720449/
https://ncbi.nlm.nih.gov/pubmed/19328787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exppara.2009.03.014
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