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Identification of a Compensatory Mutant (lpg2(−)REV) of Leishmania major Able To Survive as Amastigotes within Macrophages without LPG2-Dependent Glycoconjugates and Its Significance to Virulence and Immunization Strategies

Different Leishmania species rely to different extents on abundant glycoconjugates, such as lipophosphoglycan (LPG) and related molecules, in mammalian infections. Previously, we showed that Leishmania major deletion mutants lacking the Golgi GDP-mannose transporter LPG2, which is required for assem...

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Detalhes bibliográficos
Main Authors: Späth, Gerald F., Lye, Lon-Fye, Segawa, Hiroaki, Turco, Salvatore J., Beverley, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC415719/
https://ncbi.nlm.nih.gov/pubmed/15155672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.6.3622-3627.2004
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