Infection with arginase deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis

The balance between the products of L-arginine metabolism in macrophages regulates the outcome of Leishmania major infection. L-arginine can be oxidized by host inducible nitric oxide synthase (iNOS) to produce nitric oxide (NO), which contributes to parasite killing. In contrast, L-arginine hydroly...

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Main Authors: Muleme, Helen M, Reguera, Rosa M, Berard, Alicia, Azinwi, Richard, Jia, Ping, Okwor, Ifeoma B, Beverley, Stephen, Uzonna, Jude E
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800308/
https://ncbi.nlm.nih.gov/pubmed/19923451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803979
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