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Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating PD-1-mediated CD4(+) T cell exhaustion()
The breakdown of L-arginine to ornithine and urea by host arginase supports Leishmania proliferation in macrophages. Studies using arginase-null mutants show that Leishmania-derived arginase plays an important role in disease pathogenesis. We investigated the role of parasite-derived arginase in sec...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3737427/ https://ncbi.nlm.nih.gov/pubmed/23460745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202537 |
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