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Deficiency of Leishmania Phosphoglycans Influences the Magnitude but Does Not Affect the Quality of Secondary (Memory) Anti-Leishmania Immunity

Despite inducing very low IFN-γ response and highly attenuated in vivo, infection of mice with phosphoglycan (PG) deficient Leishmania major (lpg2-) induces protection against virulent L. major challenge. Here, we show that mice infected with lpg2- L. major generate Leishmania-specific memory T cell...

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Main Authors: Liu, Dong, Okwor, Ifeoma, Mou, Zhirong, Beverley, Stephen M., Uzonna, Jude E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679009/
https://ncbi.nlm.nih.gov/pubmed/23776605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066058
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