Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

RAP80 has a key role in the recruitment of the Abraxas–BRCC36–BRCA1–BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63-linked polyubiquitinated proteins by its tandem ubiquitin-interacting motifs (UIMs). Here, we report the crystal structure of the RAP80 tandem UI...

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Autores principales: Sato, Yusuke, Yoshikawa, Azusa, Mimura, Hisatoshi, Yamashita, Masami, Yamagata, Atsushi, Fukai, Shuya
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735169/
https://ncbi.nlm.nih.gov/pubmed/19536136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.160
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