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Identification of a potent botulinum neurotoxin A protease inhibitor using in situ lead identification chemistry
[Image: see text] Botulinum neurotoxins (BoNTs), etiological agents of the deadly food poisoning disease botulism, are the most toxic proteins currently known. By using in situ lead identification chemistry we have uncovered the first class of inhibitors that display nanomolar potency. From a 15 µM...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2006
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| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2733786/ https://ncbi.nlm.nih.gov/pubmed/16597152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol0603211 |
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