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Identification of a potent botulinum neurotoxin A protease inhibitor using in situ lead identification chemistry

[Image: see text] Botulinum neurotoxins (BoNTs), etiological agents of the deadly food poisoning disease botulism, are the most toxic proteins currently known. By using in situ lead identification chemistry we have uncovered the first class of inhibitors that display nanomolar potency. From a 15 µM...

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Bibliografiset tiedot
Päätekijät: Boldt, Grant E., Kennedy, Jack P., Janda, Kim D
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733786/
https://ncbi.nlm.nih.gov/pubmed/16597152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol0603211
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