Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polζ-dependent mechanism

Oncogenes contribute to tumorigenesis by promoting growth and inhibiting apoptosis. Here we examine the function of Sch9, the Saccharomyces cerevisiae homologue of the mammalian Akt and S6 kinase, in DNA damage and genomic instability during aging in nondividing cells. Attenuation of age-dependent i...

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Bibliografiske detaljer
Main Authors: Madia, Federica, Wei, Min, Yuan, Valerie, Hu, Jia, Gattazzo, Cristina, Pham, Phuong, Goodman, Myron F., Longo, Valter D.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2009
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733759/
https://ncbi.nlm.nih.gov/pubmed/19687253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906011
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