The Pharmacokinetics and Pharmacodynamics of Micafungin in Experimental Hematogenous Candida Meningoencephalitis: Implications for Echinocandin Therapy in Neonates

BACKGROUND: Hematogenous Candida meningoencephalitis (HCME) is a relatively frequent manifestation of disseminated candidiasis in neonates that is associated with significant mortality and neurodevelopmental abnormalities. The outcome following antifungal therapy is often suboptimal with few therape...

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Autores principales: Hope, William W., Mickiene, Diana, Petraitis, Vidmantas, Petraitiene, Ruta, Kelaher, Amy M., Hughes, Joanna E., Cotton, Margaret P., Bacher, John, Keirns, James J., Buell, Donald, Heresi, Gloria, Benjamin, Daniel K., Groll, Andreas H., Drusano, George L., Walsh, Thomas J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732769/
https://ncbi.nlm.nih.gov/pubmed/18171300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/524063
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