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How ATR turns on: TopBP1 goes on ATRIP with ATR

In this issue of Genes & Development, Mordes and colleagues (pp. 1478–1489) reveal intriguing mechanistic insights into activation of the ATR (ATM and Rad3-related) kinase critical for DNA damage resistance. They identify conserved regulatory domains within ATR and its binding partner ATRIP (ATR...

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Detalhes bibliográficos
Main Authors: Burrows, Anna E., Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732414/
https://ncbi.nlm.nih.gov/pubmed/18519633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1685108
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