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PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4(+)CD25(Hi) regulatory T cells

Regulatory CD4(+)CD25(Hi) T cells (Treg) and programmed death-1 (PD-1) molecule have emerged as pivotal players in immune regulation. However, the underlying mechanisms by which they impact antigen-specific CD8(+) immune responses in cancer patients and how they interact with each other under physio...

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Detalles Bibliográficos
Main Authors: Wang, Wenshi, Lau, Roy, Yu, Daohai, Zhu, Weiwei, Korman, Alan, Weber, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731790/
https://ncbi.nlm.nih.gov/pubmed/19651643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp072
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