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TNF downmodulates the function of human CD4(+)CD25(hi) T-regulatory cells

CD4(+)CD25(+) T-regulatory cells (Tregs) play an essential role in maintaining immunologic homeostasis and preventing autoimmunity. However, little is known about the exogenous factors that regulate their differentiation and function. Here, we report that TNF inhibits the suppressive function of bot...

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Détails bibliographiques
Auteurs principaux: Valencia, Xavier, Stephens, Geoffrey, Goldbach-Mansky, Raphaela, Wilson, Mildred, Shevach, Ethan M., Lipsky, Peter E.
Format: Artigo
Langue:Inglês
Publié: The American Society of Hematology 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895836/
https://ncbi.nlm.nih.gov/pubmed/16537805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-4567
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