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TNF downmodulates the function of human CD4(+)CD25(hi) T-regulatory cells

CD4(+)CD25(+) T-regulatory cells (Tregs) play an essential role in maintaining immunologic homeostasis and preventing autoimmunity. However, little is known about the exogenous factors that regulate their differentiation and function. Here, we report that TNF inhibits the suppressive function of bot...

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Detalhes bibliográficos
Main Authors: Valencia, Xavier, Stephens, Geoffrey, Goldbach-Mansky, Raphaela, Wilson, Mildred, Shevach, Ethan M., Lipsky, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895836/
https://ncbi.nlm.nih.gov/pubmed/16537805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-4567
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