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TNF downmodulates the function of human CD4(+)CD25(hi) T-regulatory cells

CD4(+)CD25(+) T-regulatory cells (Tregs) play an essential role in maintaining immunologic homeostasis and preventing autoimmunity. However, little is known about the exogenous factors that regulate their differentiation and function. Here, we report that TNF inhibits the suppressive function of bot...

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Autors principals: Valencia, Xavier, Stephens, Geoffrey, Goldbach-Mansky, Raphaela, Wilson, Mildred, Shevach, Ethan M., Lipsky, Peter E.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895836/
https://ncbi.nlm.nih.gov/pubmed/16537805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-4567
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