PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1(hi)CD39(+) CD4 T cells

Tumor antigen–specific CD4 T cells accumulate at tumor sites, evoking their involvement in antitumor effector functions in situ. Contrary to CD8 cytotoxic T lymphocyte exhaustion, that of CD4 T cells remains poorly appreciated. Here, using phenotypic, transcriptomic, and functional approaches, we ch...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Balança, Camille-Charlotte, Salvioni, Anna, Scarlata, Clara-Maria, Michelas, Marie, Martinez-Gomez, Carlos, Gomez-Roca, Carlos, Sarradin, Victor, Tosolini, Marie, Valle, Carine, Pont, Frédéric, Ferron, Gwénaël, Gladieff, Laurence, Vergez, Sébastien, Dupret-Bories, Agnès, Mery, Eliane, Rochaix, Philippe, Fournié, Jean-Jacques, Delord, Jean-Pierre, Devaud, Christel, Martinez, Alejandra, Ayyoub, Maha
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934837/
https://ncbi.nlm.nih.gov/pubmed/33332284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142513
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