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A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A
Pyruvate carboxylase (PC) is a conserved metabolic enzyme with important cellular functions. We report here crystallographic and cryoEM studies of S. aureus PC (SaPC) in complex with acetyl-CoA, an allosteric activator, as well as mutagenesis, biochemical and structural studies of the biotin binding...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2731552/ https://ncbi.nlm.nih.gov/pubmed/19523900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.04.008 |
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