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A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A

Pyruvate carboxylase (PC) is a conserved metabolic enzyme with important cellular functions. We report here crystallographic and cryoEM studies of S. aureus PC (SaPC) in complex with acetyl-CoA, an allosteric activator, as well as mutagenesis, biochemical and structural studies of the biotin binding...

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Autors principals: Yu, Linda P. C., Xiang, Song, Lasso, Gorka, Gil, David, Valle, Mikel, Tong, Liang
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731552/
https://ncbi.nlm.nih.gov/pubmed/19523900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.04.008
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