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Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase

Pyruvate carboxylase (PC) is a conserved multifunctional enzyme linked to important metabolic diseases. PC homotetramer is arranged in two layers with two opposing monomers per layer. Cryo-EM explores the conformational variability of PC in the presence of different substrates. The results demonstra...

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Detalhes bibliográficos
Main Authors: Lasso, Gorka, Yu, Linda P.C., Gil, David, Xiang, Song, Tong, Liang, Valle, Mikel
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956116/
https://ncbi.nlm.nih.gov/pubmed/20947019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.07.008
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