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Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase
Pyruvate carboxylase (PC) is a conserved multifunctional enzyme linked to important metabolic diseases. PC homotetramer is arranged in two layers with two opposing monomers per layer. Cryo-EM explores the conformational variability of PC in the presence of different substrates. The results demonstra...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2956116/ https://ncbi.nlm.nih.gov/pubmed/20947019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.07.008 |
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