Loading...

Synthesis of conformationally locked carbocyclic 1,3-diazepinone nucleosides as inhibitors of cytidine deaminase

We synthesized a series of carbocyclic nucleoside inhibitors of cytidine deaminase (CDA) based on a seven-membered 1,3-diazepin-2-one moiety. In the key step, the seven-membered ring was formed by a ringclosing- metathesis reaction. Therefore, the bis-allylurea moiety had to be protected by benzoyla...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Ludek, Olaf R., Schroeder, Gottfried K., Wolfenden, Richard, Marquez, Victor E.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730941/
https://ncbi.nlm.nih.gov/pubmed/18776552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nass/nrn333
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!