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Role of the Sulfonium Center in Determining Ligand Specificity of Human S-Adenosylmethionine Decarboxylase
S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in the polyamine biosynthetic pathway. Inhibition of this pathway and subsequent depletion of polyamine levels is a viable strategy for cancer chemotherapy and for the treatment of parasitic diseases. Substrate analogue inhibitors display...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2730737/ https://ncbi.nlm.nih.gov/pubmed/19527050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900590m |
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