New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C(8) Substitution in Structural Analogues of S-Adenosylmethionine

[Image: see text] S-Adenosylmethionine decarboxylase (AdoMetDC) is a critical enzyme in the polyamine biosynthetic pathway and depends on a pyruvoyl group for the decarboxylation process. The crystal structures of the enzyme with various inhibitors at the active site have shown that the adenine base...

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Detalhes bibliográficos
Main Authors: McCloskey, Diane E., Bale, Shridhar, Secrist, John A., Tiwari, Anita, Moss, Thomas H., Valiyaveettil, Jacob, Brooks, Wesley H., Guida, Wayne C., Pegg, Anthony E., Ealick, Steven E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2009
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652407/
https://ncbi.nlm.nih.gov/pubmed/19209891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801126a
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