Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma

Mechanisms of constitutive NF-κB signaling in multiple myeloma are unknown. An inhibitor of IκB kinase beta (IKKβ), targeting the classical NF-κB pathway, was lethal to many myeloma cell lines. Several cell lines had elevated expression of NIK due to genomic alterations or protein stabilization whil...

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Detalhes bibliográficos
Main Authors: Annunziata, Christina M., Davis, R. Eric, Demchenko, Yulia, Bellamy, William, Gabrea, Ana, Zhan, Fenghuang, Lenz, Georg, Hanamura, Ichiro, Wright, George, Xiao, Wenming, Dave, Sandeep, Hurt, Elaine M., Tan, Bruce, Zhao, Hong, Stephens, Owen, Santra, Madhumita, Williams, David R., Dang, Lenny, Barlogie, Bart, Shaughnessy, John D., Kuehl, W. Michael, Staudt, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730509/
https://ncbi.nlm.nih.gov/pubmed/17692804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.07.004
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