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The hypervariable region of K-Ras4B is responsible for its specific interactions with Calmodulin

K-Ras4B belongs to the family of p21 Ras GTPases, which play an important role in cell proliferation, survival and motility. The p21 Ras proteins such as K-Ras4B, K-Ras4A, H-Ras, and N-Ras, share 85% sequence homology and activate very similar signaling pathways. Only the C-terminal hypervariable re...

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Autors principals: Abraham, Sherwin J., Nolet, Ryan P., Calvert, Richard J., Anderson, Lucy M., Gaponenko, Vadim
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729490/
https://ncbi.nlm.nih.gov/pubmed/19583261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900769j
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