CK2 negatively regulates Gα(s) signaling

We present evidence, using biochemical and cellular approaches, that the kinase, CK2, negatively controls signaling via Gα(s) (or Gα(olf)) coupled to dopamine D1 and adenosine A2A receptors. Pharmacological inhibition of CK2 or CK2 knockdown by RNAi lead to elevated cAMP levels in dopamine D1 recept...

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Detaylı Bibliyografya
Asıl Yazarlar: Rebholz, Heike, Nishi, Akinori, Liebscher, Sabine, Nairn, Angus C., Flajolet, Marc, Greengard, Paul
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729026/
https://ncbi.nlm.nih.gov/pubmed/19666609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906857106
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