Forebrain overexpression of CK1δ leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD

Dopamine neurotransmission controls motor and perseverative behavior, is mediated by protein phosphorylation, and may be perturbed in disorders of attention and hyperactivity. To assess the role of casein kinase I (CK1) in the regulation of dopamine signaling, we generated a genetically modified mou...

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Detalhes bibliográficos
Main Authors: Zhou, Mingming, Rebholz, Heike, Brocia, Christine, Warner-Schmidt, Jennifer L., Fienberg, Allen A., Nairn, Angus C., Greengard, Paul, Flajolet, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840146/
https://ncbi.nlm.nih.gov/pubmed/20145109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915173107
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