Amplification of dopaminergic signaling by a positive feedback loop

Dopamine and cAMP-regulated phosphoprotein of M(r) 32,000 (DARPP-32) plays an obligatory role in most of the actions of dopamine. In resting neostriatal slices, cyclin-dependent kinase 5 (Cdk5) phosphorylates DARPP-32 at Thr-75, thereby reducing the efficacy of dopaminergic signaling. We report here...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Nishi, Akinori, Bibb, James A., Snyder, Gretchen L., Higashi, Hideho, Nairn, Angus C., Greengard, Paul
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC18851/
https://ncbi.nlm.nih.gov/pubmed/11050161
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki