Peptides modulating conformational changes in secreted chaperones: From in silico design to preclinical proof of concept

Blocking conformational changes in biologically active proteins holds therapeutic promise. Inspired by the susceptibility of viral entry to inhibition by synthetic peptides that block the formation of helix–helix interactions in viral envelope proteins, we developed a computational approach for pred...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Kliger, Yossef, Levy, Ofer, Oren, Anat, Ashkenazy, Haim, Tiran, Zohar, Novik, Amit, Rosenberg, Avi, Amir, Anat, Wool, Assaf, Toporik, Amir, Schreiber, Ehud, Eshel, Dani, Levine, Zurit, Cohen, Yossi, Nold-Petry, Claudia, Dinarello, Charles A., Borukhov, Itamar
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2009
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728974/
https://ncbi.nlm.nih.gov/pubmed/19666568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906514106
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia