Peptides modulating conformational changes in secreted chaperones: From in silico design to preclinical proof of concept

Blocking conformational changes in biologically active proteins holds therapeutic promise. Inspired by the susceptibility of viral entry to inhibition by synthetic peptides that block the formation of helix–helix interactions in viral envelope proteins, we developed a computational approach for pred...

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Detalhes bibliográficos
Main Authors: Kliger, Yossef, Levy, Ofer, Oren, Anat, Ashkenazy, Haim, Tiran, Zohar, Novik, Amit, Rosenberg, Avi, Amir, Anat, Wool, Assaf, Toporik, Amir, Schreiber, Ehud, Eshel, Dani, Levine, Zurit, Cohen, Yossi, Nold-Petry, Claudia, Dinarello, Charles A., Borukhov, Itamar
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728974/
https://ncbi.nlm.nih.gov/pubmed/19666568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906514106
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