Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation

BACKGROUND: The expression of heat shock protein gp96 is strongly correlated with the degree of tissue inflammation in ulcerative colitis and Crohn’s disease, thereby leading us to the hypothesis that inhibition of expression via gp96-II peptide prevents intestinal inflammation. METHODS: We employed...

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Vydáno v:Front Immunol
Hlavní autoři: Nold-Petry, Claudia A., Nold, Marcel F., Levy, Ofer, Kliger, Yossef, Oren, Anat, Borukhov, Itamar, Becker, Christoph, Wirtz, Stefan, Sandhu, Manjeet K., Neurath, Markus, Dinarello, Charles A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732239/
https://ncbi.nlm.nih.gov/pubmed/29312281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01531
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