The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion. It was recently shown that TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors...

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Bibliografische gegevens
Hoofdauteurs: Stanietsky, Noa, Simic, Hrvoje, Arapovic, Jurica, Toporik, Amir, Levy, Ofer, Novik, Amit, Levine, Zurit, Beiman, Meirav, Dassa, Liat, Achdout, Hagit, Stern-Ginossar, Noam, Tsukerman, Pinhas, Jonjic, Stipan, Mandelboim, Ofer
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2009
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764881/
https://ncbi.nlm.nih.gov/pubmed/19815499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903474106
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