Topoisomerase I Levels in the NCI-60 Cancer Cell line Panel Determined by Validated ELISA and Microarray Analysis and Correlation with Indenoisoquinoline Sensitivity

Topoisomerase I (Top1) is a proven target for cancer therapeutics, and the level of Top1 in tumors has been employed as a biomarker for chemotherapeutic efficacy. In this study, we report the development and validation of a two-site enzyme chemiluminescent immunoassay for Top1, which we used to meas...

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Главные авторы: Pfister, Thomas D., Reinhold, William, Agama, Keli, Gupta, Shalu, Khin, Sonny A., Kinders, Robert J., Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H., Pommier, Yves
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728499/
https://ncbi.nlm.nih.gov/pubmed/19584232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0016
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