Exon array analyses across the NCI-60 reveals potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron

Because Topoisomerase I (TOP1) is critical for the relaxation of DNA supercoils and because it is the target for the anticancer activity of camptothecins, we assessed TOP1 transcript levels in the 60 cell line panel (the NCI-60) of the National Cancer Institute's anticancer drug screen. TOP1 ex...

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Bibliographic Details
Main Authors: Reinhold, William C., Mergny, Jean-Louis, Liu, Hongfang, Ryan, Michael, Pfister, Thomas D., Kinders, Robert, Parchment, Ralph, Doroshow, James, Weinstein, John N., Pommier, Yves
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922994/
https://ncbi.nlm.nih.gov/pubmed/20215517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3528
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