Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1

Histone H2B monoubiquitination by Rad6/Bre1 is required for the trimethylation of both histone H3K4 and H3K79 by COMPASS and Dot1 methyltransferases, respectively. The dependency of methylation at H3K4 and H3K79 on the monoubiquitination of H2BK123 was recently challenged, and extragenic mutations i...

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Autors principals: Nakanishi, Shima, Lee, Jung Shin, Gardner, Kathryn E., Gardner, Jennifer M., Takahashi, Yoh-hei, Chandrasekharan, Mahesh B., Sun, Zu-Wen, Osley, Mary Ann, Strahl, Brian D., Jaspersen, Sue L., Shilatifard, Ali
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2009
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728409/
https://ncbi.nlm.nih.gov/pubmed/19667127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906005
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