Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

Epigenetic modifications of chromatin play an important role in the regulation of gene expression. KMT4/Dot1 is a conserved histone methyltransferase capable of methylating chromatin on Lys79 of histone H3 (H3K79). Here we report the identification of a multisubunit Dot1 complex (DotCom), which incl...

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Detalhes bibliográficos
Main Authors: Mohan, Man, Herz, Hans-Martin, Takahashi, Yoh-Hei, Lin, Chengqi, Lai, Ka Chun, Zhang, Ying, Washburn, Michael P., Florens, Laurence, Shilatifard, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841335/
https://ncbi.nlm.nih.gov/pubmed/20203130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1898410
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