Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1

Histone H2B monoubiquitination by Rad6/Bre1 is required for the trimethylation of both histone H3K4 and H3K79 by COMPASS and Dot1 methyltransferases, respectively. The dependency of methylation at H3K4 and H3K79 on the monoubiquitination of H2BK123 was recently challenged, and extragenic mutations i...

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Detalhes bibliográficos
Main Authors: Nakanishi, Shima, Lee, Jung Shin, Gardner, Kathryn E., Gardner, Jennifer M., Takahashi, Yoh-hei, Chandrasekharan, Mahesh B., Sun, Zu-Wen, Osley, Mary Ann, Strahl, Brian D., Jaspersen, Sue L., Shilatifard, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728409/
https://ncbi.nlm.nih.gov/pubmed/19667127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906005
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