Structure of the Murine Constitutive Androstane Receptor Complexed to Androstenol: A Molecular Basis for Inverse Agonism

The nuclear receptor CAR is a xenobiotic responsive transcription factor that plays a central role in the clearance of drugs and bilirubin while promoting cocaine and acetaminophen toxicity. In addition, CAR has established a “reverse” paradigm of nuclear receptor action where the receptor is active...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Shan, Li, Vincent, Jeremy, Brunzelle, Joseph S., Dussault, Isabelle, Lin, Min, Ianculescu, Irina, Sherman, Mark A., Forman, Barry M., Fernandez, Elias J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2004
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727924/
https://ncbi.nlm.nih.gov/pubmed/15610734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2004.11.037
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