A Structural Model of the Constitutive Androstane Receptor Defines Novel Interactions That Mediate Ligand-Independent Activity

Unlike classical nuclear receptors that require ligand for transcriptional activity, the constitutive androstane receptor (CAR) is active in the absence of ligand. To determine the molecular contacts that underlie this constitutive activity, we created a three-dimensional model of CAR and verified c...

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Detalhes bibliográficos
Main Authors: Dussault, Isabelle, Lin, Min, Hollister, Kevin, Fan, Ming, Termini, John, Sherman, Mark A., Forman, Barry M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133936/
https://ncbi.nlm.nih.gov/pubmed/12101224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.15.5270-5280.2002
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