A Structural Model of the Constitutive Androstane Receptor Defines Novel Interactions That Mediate Ligand-Independent Activity

Unlike classical nuclear receptors that require ligand for transcriptional activity, the constitutive androstane receptor (CAR) is active in the absence of ligand. To determine the molecular contacts that underlie this constitutive activity, we created a three-dimensional model of CAR and verified c...

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Bibliographische Detailangaben
Hauptverfasser: Dussault, Isabelle, Lin, Min, Hollister, Kevin, Fan, Ming, Termini, John, Sherman, Mark A., Forman, Barry M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Transcriptional Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC133936/
https://ncbi.nlm.nih.gov/pubmed/12101224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.15.5270-5280.2002
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