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Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif
The tumor suppressor p53 has evolved a MDM2-dependent feedback loop that promotes p53 protein degradation through the ubiquitin–proteasome system. MDM2 is an E3-RING containing ubiquitin ligase that catalyzes p53 ubiquitination by a dual-site mechanism requiring ligand occupation of its N-terminal h...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2725272/ https://ncbi.nlm.nih.gov/pubmed/19568783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12154-009-0019-5 |
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