Loss of Phosphatase and tensin homologue deleted on chromosome 10 engages ErbB3 and IGF-IR signaling to promote antiestrogen resistance in breast cancer

Knockdown of the tumor suppressor phosphatase PTEN with shRNA in three estrogen receptor (ER)-positive breast cancer cell lines resulted in increased PI3K and AKT activities, resistance to tamoxifen and fulvestrant, and hormone-independent growth. PTEN knockdown induced the upregulation of ER transc...

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Detalhes bibliográficos
Main Authors: Miller, Todd W., Pérez-Torres, Marianela, Narasanna, Archana, Guix, Marta, Stål, Olle, Pérez-Tenorio, Gizeh, Gonzalez-Angulo, Ana M., Hennessy, Bryan T., Mills, Gordon B., Kennedy, J. Phillip, Lindsley, Craig W., Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724871/
https://ncbi.nlm.nih.gov/pubmed/19435893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0042
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